KPV is one of the smallest peptides but it has some lofty claims.
Anti-inflammatory, antimicrobial. anti-fungal and more.
We wanted to find out if they were true. TL;DR – surprisingly, they are!
Skip down to: dosage info • where to purchase
OR see: KPV Short Guide, for just the basics!
In about two weeks it relieved our yeast, bloating, IBS, MCAS, hives / red flushing, allergic asthma, food reactions, and even acne!
In 4 weeks it also resolved recurrent SIBO, POTS, fatigue and all lifetime allergies.
It can quickly stop / prevent PANS flares and was key to recovering from long COVID.
- Best parts: effective with a very small (oral) dose, tasteless, does not require a prescription
- Less than ideal: works most effectively for us with frequent dosing (every few hours)
So let’s unpack it…
What can the KPV peptide do?
Taken orally KPV has incredible healing properties.
- Potent anti-inflammatory
- Can heal IBS, SIBO, Crohn’s disease, ulcerative colitis – all GI conditions
- Mast Cell stabilizer
- Antifungal – kills Candida yeast (more effective than diflucan) and Mold
- Antimicrobial – kills bacteria
- effective for tics & OCD (PANS)
- possibly Lyme (research ongoing)
- Penetrate biofilm and prevent their formation
- Attack drug resistant bacteria & fungi
- Prevents allergic asthma
- Treats inflammatory skin conditions: eczema, acne, psoriasis
- Gentle immune modulation: reduces cytokine storms – does not cause imbalance or allergies
- Regenerates nerves – speeds wound healing
- Potential to help with Parkinson’s, Alzheimer’s, multiple sclerosis, POTS and other neurodegenerative conditions
What is KPV Peptide?
KPV peptide is the amino acids Lysine-Proline-Valine joined together by peptide bonds.
that make up proteins
Like other peptides, it can reach every part of our body, acting as a messenger, signaling glands and proteins to perform tasks.
For more on Peptide Basics see our: PEPTIDES 101
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A specific task KPV initiates is the inactivation of inflammatory pathways inside our cells.
Not only can it diminish inflammation, it also has antimicrobial effects against pathogens, bacteria, candida, and mold. It can also break down and prevent biofilms.
“Considering how fungal infections are known to quickly develop resistance against existing treatments, it’s possible that with KPV we are already close to eradicating a multi-decade problem in the medical industry.”
“In addition to its anti-candida treatment properties, it also works to restore microbiome balance and treat SIBO infections, irritable bowel syndrome (IBS), and Inflammatory bowel diseases like Ulcerative Colitis and Crohn’s disease.” – Jeffrey Mark, MD
For more, read our post: Why Peptides are the New Go-To for Fighting Infections — better than herbs
•••
KPV can also help stabilize mast cells in our immune system.
People suffering from histamine overload – allergies, hives, flushing, itching skin conditions, anxiety and MCAS, finally have a lifeline!
Research shows KPV can speed wound healing, reduce infection, fight inflammation both inside the body and on the skin.
It improves the organization of collagen fibers and limits the formation of scar tissue.
KPV is also able to decrease tumor number and the proliferation of malignant colon cells.
If that’s not enough, KPV has broad reaching effects for any of the myriad issues resulting from ongoing inflammation.
Consequences of Chronic Inflammation
How does it work?
In the GI System
KPV stops the production of proinflammatory cytokines in both intestinal epithelial cells and immune cells. (R)
It also helps the gut cells regenerate and repair by influencing the pathways that control cell growth and healing.
A healthy gut with tight junctions can absorb nutrients more effectively and prevent harmful substances from entering the bloodstream – which in turn, causes inflammation and immune responses.
Bacterial and fungal infections / mold toxicity
KPV has a dual approach:
1. Disrupting normal bacterial and fungal cell functioning, hindering their ability to grow and multiply / spread – it can penetrate biofilms and eliminate even drug resistant microbes.
2. Assisting immune cells to identify and attack bacterial and fungal invaders more effectively
From our group:
Immune System / Mast Cells
KPV helps improve how the immune system works by regulating cells that fight infection (macrophages).
It does this by signaling them to work appropriately and not overreact (which leads to inflammation and mast cell activation).
Controlling Inflammation
KPV enters the nucleus of the cell and signals to inhibit cytokines and stop the cascade response of inflammatory pathways – also preventing the resulting downstream inflammation.
Nerve Regeneration
It can help combat the effects of aging and other medical conditions on nerve health.
As a C3 peptide, it promotes cell proliferation, migration, reprogramming, and axonal regeneration. This leads to functional motor recovery after peripheral nerve injury.
In Summary
KPV’s targeted mechanisms allow it to act as a molecular multitasker, soothing inflammation, combating pathogens and strengthening immune harmony.
Anti-inflammatory
- KPV enters cells and blocks pro-inflammatory pathways (“switches” for genes producing cytokines) — thereby calming excessive inflammation (Luger et al., 2017)
Antifungal and antimicrobial
- KPV disrupts pathogen cell membranes and biofilms, inhibiting the growth of microbes independently of white blood cells (Cândido et al., 2019)
Immune modulation
- KPV fine-tunes immunity by enhancing regulatory T-cell activity and balancing innate and adaptive responses
- Unlike some antibiotics that may suppress immune function by disrupting gut microbiota, KPV supports a robust immune system while fighting infections
These features make it a unique ally for healing tissues and maintaining balance.
First line treatment or last resort?
I initially heard of KPV peptide as a last resort if other supplements don’t work for mast cell activation or gut issues (SIBO, IBS, UC, etc…)
After trying dozens of supplements and also KPV, I think that advice is probably backwards and also cost ineffective!
For us, KPV peptide works significantly superior to other supplements and medications, with no side effects.
Our Experience
I know the benefits of KPV seem unbelievable. I certainly thought they were too good to be true.
But as it turns out, it actually delivers!
- It has cured our food reactions, gut symptoms, yeast, SIBO and bloating.
- At the end of every day, both of us have no bloating and flat abdomens, something I can’t recall the last time I have seen.
- It has eliminated my daughter’s red flushing that she’s had for over a decade with exposure to heat from sunlight and showering. Also no itchiness.
- The allergic asthma I struggled with daily is gone. My lungs have abundant oxygen – I didn’t realize other people could breathe so well!
- My nasal allergies to dust mites, pollen, ragweed and many other triggers have all disappeared beginning around 2 weeks into use.
- I can also now tolerate fragrance exposure!
- Update: Sept. 6, 2025 – it’s the height of ragweed season (my worst allergy that I’ve had my entire lifetime). I just spent 3 hours outdoors in the red zone (Chicago suburbs) – completely zero allergies, not even a hint of an issue. Even my lungs are unaffected 🥰 To me, this was the ultimate test – my genetics have changed 🙏🏻
- After just one week, we expanded our diets more than we have in 3 years.
- We have witnessed various rapid wound and acne healing and smoothed skin.
- It has stopped and also prevented PANS Flares for my daughter – more on how we treat PANS is in my post here.
- Our minds are clearer, calmer, less inflamed. I suspect KPV could help significantly with ADD & ADHD.
- I have no ruminating thoughts and no anxiety, even in situations where I typically would.
- Update: After one month, my long covid induced POTS (vestibular – dizziness and lightheadedness) is also gone.
- This marks the final piece in my 2 year journey to Long Covid Recovery. 🤍
Details for how we dose and where we purchased (Integrative Peptides w/ coupon SAVE 10) – are below the next section.
A Complementary peptide
I was so impressed with KPV I began to research what other peptides we might try.
One that quickly caught my interest was Larazotide Acetate (LA).
It’s a simple peptide with one action – to decrease tight junction permeability in the gut by blocking receptors – temporarily closing a “leaky gut.”
~ Why would we want LA when KPV can do the same thing?
KPV is repairing the gut. That takes time, everyone is unique, some say 3 months, could be less. TB4 Frag can help speed healing. With a healed GI tract, tight junctions are better closed.
But LA peptide does it instantly via signaling (as a temporary / bandaid treatment).
One benefit of using LA in the early stages of KPV use, is that it can reduce possible die off reactions from KPV killing yeast and bacteria.
With a solid gut lining, the dead organisms are more efficiently ushered out of the body and are less likely to escape the gut to cause harmful symptoms.
We added it about 14 days after beginning KPV and it’s been impressive. You can read about it more in my post here.
Now, back to KPV specifics!
Calculating Dosage for KPV 📝
A challenge with using some peptides can be their short half lives and unknown signaling duration. Many have a half life of only 2-30 minutes.
For KPV specifically, neither I nor Chat GPT could find specific half life or signaling duration information.
From what I read, it is estimated that the signaling could last as little as “several hours.”
My observations are:
- It works immediately
- Optimum effectiveness for acute issues is less than 2 hours.
- Required dose at one time is very small, approx 50mcg (1/10th of a capsule) and sometimes less.
- In early use, should be repeated throughout the day (before meals and snacks).
Our KPV Dosing
Below is what we do which is less than typical dosing.
Our capsules are 500mcg
When we started, I divided our total into about 5 doses throughout day. You don’t have to do this but at least 3x would be better than all at once.
Example Schedule:
All doses are approximate & exact amount does not matter.
*Some people begin with less, a toothpick sized dose and maintain it to help avoid die off symptoms*
• Week 1: less than 1/10th of a cap (50mcg) up to 5x per day. This is a total of 250 mcg or half of the capsule in one day.
• Weeks 2-5: Gradually increase to 125 mcg (1/4 capsule) up to 4x/day, reduce if die off or irritability occurs.
• Weeks 6-8: Adjust as needed, not more than 1 cap per day, still divided 3x if possible
• Month 3: Begin to experiment with less
• Month 4+: if remain symptom free, move toward a maintenance dose of 50 mcg 2x/day (AM/PM)
•••
• Spray Option: ~250 mcg per spray; use an eye dropper (~100 mcg/drop) and dilute with water for microdosing (50 mcg = 1 drop of 50/50 diluted solution).
My observations after 5 months
I completely stopped taking KPV. After about 2 weeks without it, very slight MCAS symptoms began slowly coming back but did not worsen.
After 6 weeks without taking any KPV at all, I tried microdosing a maintenance dose of:
1/10th of a cap, twice a day – AM / PM
Everyone is different, but this keeps me symptom free.
Our video explains dosing and much more!
Here is a pdf with our KPV Protocol for PANS, MCAS, POTS, Long COVID & chronic illnesses
How we take it
We pour a small, inexact amount under the tongue or into a capsule typically before every meal or large snack.
It’s practically tasteless and the slight taste is mild / pleasant. You could dilute with a small amount of water.
We tolerated it well and had no die off symptoms.
Any digestive issues following food (such as uneasiness or SIBO gas) should be resolved, if they aren’t, take more and I bet they will be!
Around week 3, we were able to space it out more without having GI issues when eating snacks in between doses.
If we were taking it exclusively for non-digestive issues, I would still divide the doses so it is effective for a longer period of time.
Under the tongue vs. In a capsule
We experimented to determine the difference between these methods.
I observed that under the tongue helps more with systemic issues (including GI but not as directly) and in a capsule helps direct it more to the GI tract.
Confirmed in our FB Group: “The company told me that taking capsules would impact the gut first, while the sublingual spray [or similarly under the tongue powder] would affect the brain first. They said either way they would both eventually reach all systems of the body.”
My advice is to experiment with both ways and see what works best for you!
Increasing the dose / Die off
KPV is a potent antifungal and antimicrobial so if you have pathogens, go slow and watch for any die off / herx reactions.
Die off symptoms happen when you kill yeast or bacteria more quickly than your body can eliminate the dead toxins.
They often look like an amplified version of the same symptoms the yeast or bacteria itself was causing.
Finding a balance between an effective dose and one that produces too much die off is key if you have yeast or bacterial overgrowth.
Because die off can create an acidic environment, some people who are prone to acid reflux will experience it when taking KPV.
These people have found that when taking it in a capsule instead of under the tongue, they don’t get the reflux.
If you need more help, the Gastric Mucin Bioregulator, Gastrogen is excellent at stopping acid reflux even for tough cases. See here for more.
Because KPV concurrently helps heal the gut, in our experience, the die off is minimal compared to other methods of treating yeast or bacteria.
However, it is also stronger than other methods, so please go slow!
Some traditional symptoms of general die off (not specific to KPV) can include: brain fog, loose stools / constipation, fatigue, irritability, headaches, skin issues, acid reflux (for esophageal candida), fever, nausea.
Expect more GI specific die off if you use it in a capsule rather than under the tongue.
I had slight die off issues (brain fog, irritability, fatigue and GI issues) when I reached 1 cap per day. My daughter had some at each dose increase. After detoxing they have been minimal and very much worth the gains on the other side!
If you have die off, it’s important to take even less and in some cases take some days off.
It is ok to pulse the dosing as needed.
Die off can look exactly like your past symptoms and it can mask all gains.
For our detox we use activated charcoal as a Binder at bedtime, lots of hydration and sometimes if needed, ammonia reducing strategies (such as 1/4 cap BH4) from the blog post I wrote – Detox the die off
Additionally you could consider Liver and Kidney bioregulators – see the detox post above for them also!
How to purchase KPV
KPV peptide capsule are sold directly from the manufacturer, Integrative Peptides on their site:
integrativepeptides.com/product/kpv/
We use the coupon: SAVE10 for 10% off any order & shipping in USA is free.
(The price for KPV after the coupon is $135)
They will ship overseas and to Canada also.
I recommend buying it directly from them.
We have heard of suspicious products and delays with some resellers (price is the same everywhere).
Important to note:
Integrative Peptide’s KPV is a naturally occurring isomer – acetylated and amidated to increase its stability, bioavailability, and effectiveness.
This also makes it last longer.
No other brands of KPV including compounding pharmacies or Biolab are Acetylated or Amidated. These tend to have a lower efficacy.
Some group members have reported issues with other brands or compounded KPV not working as well.
Spray version
Integrative Peptides also sells a KPV oral spray <Click for product
It will be more difficult to do micro dosing or experiment with using inside capsules.
Update: January 2025
We have had GREAT success with the spray for many topical issues involving bacteria, yeast, inflammation or mast cells including:
Bug bites, acne, rashes, sinus infections, and more!
It works great on the skin and is the consistency of water.
I spray one spray onto my hand and dab it with a fingertip to apply.
Surprisingly, for us it also had transdermal effects!
I don’t recommend using it this way to treat systemic issues because it would be difficult to know and measure dosing.
For any questions including “Is microdosing really necessary?” and topics that weren’t in this post, please visit our
FAQ page
In summary
KPV peptide turned out to be the best gut decision!
I believe peptides are going to forever change the way we treat infections, diseases, inflammation and health in general. I’m looking forward to finding others that we love.
DSIP, (delta sleep-inducing peptide), I’ve got my shut eye on you!
Update: Thank you for all of the interest in this post! Due to popular request, I created a Facebook Chat to share experiences and continue the discussion about peptides!
Update 2.0: Initial reports coming in have been remarkable! Keep them coming. ☺️
July 2024: KPV has now helped thousands from our group. We are so thankful for everyone who has shared stories!
I made the chat because it was hard to keep up with messages and thought we could learn more together!
Some feedback from the group ☺️
Dairy husband took 1/4 cap each, under the tongue.
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You may like some of our other posts, including:
Our REVIEW of the 40 Peptides we’ve tried please click the link and also see more below.
Our Resources Page with all of our Peptide related content!
Condensed version of this post:
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Diary of Recovery 
This is amazing! Can’t wait to try with my Ella, and self. How soon did you notice results/healing?
We noticed initial results within 2 minutes! 🙂 at about 3 weeks we have significant healing – to where we don’t need to take it all throughout the day.